BLOOD SUGAE STUDIES IN THE BULLFROG, RAN A CATESBIANA1

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Abstract
Over a period of 2 1/2 years, blood glucose values of 154 normal bullfrogs averaged 13.51 mg% with 28% showing complete sugar absence. No correlation could be found between blood glucose level and apparent nutritional state of the animal or season of the year. Among factors which induced hyperglycemia were repeated removal of blood samples (without albumin restitution), intra-arterial glucagon >epinephrine, and extracts of bullfrog, angler fish, and dogfish gastrointestinal tissues presumed to contain glucagon. Alloxan, beef STH, and bullfrog pituitary extract failed to raise the blood sugar level significantly. Bullfrogs were somewhat less tolerant of intra-arterial-ly injected monosaccharides than rabbits and responded slowly to exogenous insulin. A brief discussion follows on the relationship of these data to the apparently normal maintenance of an hypoglycemic state in bullfrogs.

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