THE EFFECT OF BZ-55 (CARBUTAMIDE) ON THE GLUCOSE-6-PHOSPHATASE ACTIVITY IN THE LIVERS OF INTACT AND ALLOXANIZED FEMALE RATS
- 1 January 1957
- journal article
- Published by Canadian Science Publishing in Canadian Journal of Biochemistry and Physiology
- Vol. 35 (1) , 215-218
- https://doi.org/10.1139/y57-027
Abstract
The ingestion of the sulphonylurea BZ-55 (0.5 g./kg. body weight) by normal female rats for 8 days leads to a significant depression in the level of glucose-6-phosphatase activity in the liver of these animals. The glucose-6-phosphatase activity of the liver in alloxanized rats is higher than that of paired-fed control animals. The ingestion of BZ-55 by alloxanized rats causes this activity to be further increased as shown by comparison with the glucose-6-phosphatase activity in alloxanized, individually paired-fed controls. The differences in the effects of BZ-55 in normal and alloxanized animals are discussed.Keywords
This publication has 1 reference indexed in Scilit:
- THE EFFECT OF DIABETES AND FASTING ON LIVER GLUCOSE-6-PHOSPHATASEProceedings of the National Academy of Sciences, 1954