p53 increases experimental metastatic capacity of murine carcinoma cells.
Open Access
- 1 May 1988
- journal article
- research article
- Published by Taylor & Francis in Molecular and Cellular Biology
- Vol. 8 (5) , 2078-2081
- https://doi.org/10.1128/mcb.8.5.2078
Abstract
Transfection of a cloned p53 gene into a murine bladder carcinoma cell with a low metastatic capacity led to elevated levels of p53 protein in clonal transfectants. After intravenous inoculation into syngeneic mice, p53-transfected clones showed significantly increased metastatic potential in comparison with control transfectants. The observed change did not seem to be due to a change in growth potential per se since the cell lines showed similar growth properties in vitro.This publication has 31 references indexed in Scilit:
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