Chronic Granulomatous Disease

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Abstract
SURVIVAL beyond adolescence is unusual in chronic granulomatous disease of childhood because of a marked susceptibility to serious bacterial and fungal infection.1Therefore, diagnosis of this disease in patients older than 18 years of age is rarely reported.2,3Recently, we have diagnosed chronic granulomatous disease in a 27-year-old man suffering from atypical mycobacterial pneumonitis and osteomyelitis. Report of a Case A 27-year-old man was referred to the National Institutes of Health (NIH). He had had pneumonitis for two months, and his past history included a staphylococcal thigh abscess and several bouts of facial cellulitis. The patient's 12-year-old sister was known to have chronic granulomatous disease complicated by chronicNocardiaosteomyelitis, and a brother had died of disseminated tuberculosis at 1 year of age. Two months prior to referral, pleuritic chest pain developed with fever, night sweats, chills, and a 13.5-kg (30-lb) weight loss. A chest x-ray film showed

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