Hedamycin intercalates the DNA helix and, through carbohydrate-mediated recognition in the minor groove, directs N7-alkylation of guanine in the major groove in a sequence-specific manner
- 1 April 1995
- journal article
- Published by Elsevier in Chemistry & Biology
- Vol. 2 (4) , 229-240
- https://doi.org/10.1016/1074-5521(95)90273-2
Abstract
No abstract availableKeywords
This publication has 31 references indexed in Scilit:
- Altromycin B Threads the DNA Helix Interacting with Both the Major and the Minor Grooves To Position Itself for Site-Directed Alkylation and Guanine N7Journal of the American Chemical Society, 1995
- Structure of the altromycin B (N7-guanine)-DNA adduct. A proposed prototypic DNA adduct structure for the pluramycin antitumor antibioticsBiochemistry, 1993
- Novel antitumor antibiotics, saptomycins. II. Isolation, physico-chemical properties and structure elucidation.The Journal of Antibiotics, 1993
- Sapurimycin, new antitumor antibiotic produced by Streptomyces. Structure determination.The Journal of Antibiotics, 1991
- Structures of the novel anthraquinone antitumor antibiotics, DC92-B and DC92-D.The Journal of Antibiotics, 1990
- Ankinomycin, a potent antitumor antibiotic.The Journal of Antibiotics, 1989
- Isolation and Structure Elucidation of Some Components of the Antitumor Antibiotic Mixture ‘Rubiflavin’Helvetica Chimica Acta, 1987
- Studies on a new antibiotic SF-2330. I. Taxonomy, isolation and characterization.The Journal of Antibiotics, 1986
- Isolation and Structure of a New Antibiotic Related to Rubiflavin AHelvetica Chimica Acta, 1985
- Structure and properties of major largomycin FII chromophore components.The Journal of Antibiotics, 1984