Prevention of Sudden Cardiac Death by Dietary Pure ω-3 Polyunsaturated Fatty Acids in Dogs

Publisher Website
Google Scholar
Abstract
Background—Rat diets high in fish oil have been shown to be protective against ischemia-induced fatal ventricular arrhythmias. Increasing evidence suggests that this may also apply to humans. To confirm the evidence in animals, we tested a concentrate of the free fish-oil fatty acids and found them to be antiarrhythmic. In this study, we tested the pure free fatty acids of the 2 major dietary ω-3 polyunsaturated fatty acids in fish oil: cis-5,8,11,14,17-eicosapentaenoic acid (C20:5ω-3) and cis-4,7,10,13,16,19-docosahexaenoic acid (C22:6ω-3), and the parent ω-3 fatty acid in some vegetable oils, cis-9,12,15-α-linolenic acid (C18:3ω-3), administered intravenously on albumin or a phospholipid emulsion. Methods and Results—The tests were performed in a dog model of cardiac sudden death. Dogs were prepared with a large anterior wall myocardial infarction produced surgically and an inflatable cuff placed around the left circumflex coronary artery. With the dogs running on a treadmill 1 month after the surgery, ...

This publication has 26 references indexed in Scilit: