Role of the extra-follicular compartment in the ovulation of isolated rabbit ovarian follicles

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Abstract
Ovulation was never observed even in the presence of gonadotrophins, when preovulatory follicles isolated from estrous does were cultured in vitro (n = 112). If the follicles were co-cultured with pieces of ovarian tissue and gonadotropins, then 50% ovulated (P < 0.01). Attempts to replace the ovarian tissue by various steroid hormones or prostaglandins [PG] did not result in follicular rupture except when PGE-2 was used (23.8%, P < 0.05). Gonadotropins may have an immediate (< 1 h) action upon the follicle and ovarian interstitial tissue simultaneously. The response of the ovarian tissue to gonadotropins is essential for eventual follicular rupture and involves PGE-2.

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