Studies of Anti-Rabbit Heterophile Agglutinins in Human Serum

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Abstract
The majority of the naturally occurring anti-rabbit erythrocyte agglutinins in human serum was found to be of gamma M variety. Zone centrifugations always revealed the presence of some activity of the 7S fraction, and DEAE -sephadex chromatography indicated that the 7S material was mainly gamma G globulia Pooled normal serum agglutinated rabbit erythrocytes at 16-fold higher dilution than sheep erythrocytes. Four different types of experiments were carried out to compare the agglutinability of rabbit and sheep erythrocytes. All studies indicated that rabbit erythrocytes are Inherently more agglutinable. Sera from patients with psoriasis agglutinated rabbit erythrocytes in average at one 2-fold dilution step lower dilution than control sera. Likewise, the psorlatic sera had slightly lower gamma M globulin values. The sera from patients with multip?e myeloma or macroglobulinemia showed a marked depression of the immunoglobulins other than the paraproteln. With a few exceptions, these sera had definitely lower anti-rabbit erythrocyte titers than the control sera. All the sera from patients with hypogammaglobulinemia had low titer values.

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