Effects of growth hormone‐releasing factor and somatostatin on growth hormone secretion and cellular cyclic AMP levels
- 1 January 1985
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 179 (1) , 12-16
- https://doi.org/10.1016/0014-5793(85)80180-0
Abstract
Human pancreatic growth hormone-releasing factor (GRF-44-NH2) stimulated growth hormone (GH) secretion and intracellular cyclic AMP levels in cultured pituitary cells from both sheep and rat. Somatostatin (SRIF), over a wide range of doses and time, showed no significant effect on the elevated cyclic AMP levels in sheep cells, but did block the GH release in a dose-dependent manner. In rat cells, however, SRIF inhibited GRF-stimulated cyclic AMP levels by 75% maximum (still 8-fold greater than the basal levels) and GH release to almost half the basal value. We conclude that somatostatin inhibits GRF-elevated cyclic AMP levels in rat pituitary cells but not in sheep cells.Keywords
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