Amphiphysin 2 (Bin1) and T-Tubule Biogenesis in Muscle
Top Cited Papers
- 16 August 2002
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 297 (5584) , 1193-1196
- https://doi.org/10.1126/science.1071362
Abstract
In striated muscle, the plasma membrane forms tubular invaginations (transverse tubules or T-tubules) that function in depolarization-contraction coupling. Caveolin-3 and amphiphysin were implicated in their biogenesis. Amphiphysin isoforms have a putative role in membrane deformation at endocytic sites. An isoform of amphiphysin 2 concentrated at T-tubules induced tubular plasma membrane invaginations when expressed in nonmuscle cells. This property required exon 10, a phosphoinositide-binding module. In developing myotubes, amphiphysin 2 and caveolin-3 segregated in tubular and vesicular portions of the T-tubule system, respectively. These findings support a role of the bilayer-deforming properties of amphiphysin at T-tubules and, more generally, a physiological role of amphiphysin in membrane deformation.Keywords
This publication has 26 references indexed in Scilit:
- Amphiphysin is necessary for organization of the excitation–contraction coupling machinery of muscles, but not for synaptic vesicle endocytosis inDrosophilaGenes & Development, 2001
- Generation of high curvature membranes mediated by direct endophilin bilayer interactionsThe Journal of cell biology, 2001
- Caveolin-3 Null Mice Show a Loss of Caveolae, Changes in the Microdomain Distribution of the Dystrophin-Glycoprotein Complex, and T-tubule AbnormalitiesJournal of Biological Chemistry, 2001
- Tandem Arrangement of the Clathrin and AP-2 Binding Domains in Amphiphysin 1 and Disruption of Clathrin Coat Function by Amphiphysin Fragments Comprising These SitesPublished by Elsevier ,2000
- PHOSPHOINOSITIDE LIPIDS AS SIGNALING MOLECULES: Common Themes for Signal Transduction, Cytoskeletal Regulation, and Membrane TraffickingAnnual Review of Cell and Developmental Biology, 1998
- Amphiphysin II (SH3P9; BIN1), a Member of the Amphiphysin/Rvs Family, Is Concentrated in the Cortical Cytomatrix of Axon Initial Segments and Nodes of Ranvier in Brain and around T Tubules in Skeletal MuscleThe Journal of cell biology, 1997
- Caveolin-3 Associates with Developing T-tubules during Muscle DifferentiationThe Journal of cell biology, 1997
- Intracellular Trafficking of Cholesterol Monitored with a CyclodextrinJournal of Biological Chemistry, 1996
- Induction of mutant dynamin specifically blocks endocytic coated vesicle formation.The Journal of cell biology, 1994
- FORMATION OF ELABORATE NETWORKS OF T-SYSTEM TUBULES IN CULTURED SKELETAL MUSCLE WITH SPECIAL REFERENCE TO THE T-SYSTEM FORMATIONThe Journal of cell biology, 1968