[des-Asp1Angiotensin II in the Dog: Blood Levels and Effect on Aldosterone

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Abstract
Circulating levels of [des-Asp1angiotensin II ([des-Asp1-AII), angiotensin II (All), and aldosterone were measured in five conscious beagle dogs before and during iv infusion of [des-Asp1AII at rates of 3, 6,12, and 24 ng/kg/min. The animals were studied after 4 days on a normal sodium and potassium diet and again after a period of sodium depletion accomplished by iv furosemide (2–5 mg/kg) and 4 days of low sodium diet (2–5 mmol/day). Compared to the normal sodium diet, sodium depletion resulted in increases in the plasma levels of aldosterone from 10 ± 2 (SE) to 66 (16–116) ng/100 ml of All from 16 ± 4 to 52 ± 13 pmol/liter and of [des-Asp1AII from 2 ± 0.7 to 12 ± 4 pmol/liter. Incremental infusions of [des-Asp1]AII in the sodium replete state resulted in progressive increases in the plasma levels of aldosterone in all dogs.In comparison with a previous study in which dogs were infused with All, it was apparent that [des-Asp1]AII was equally or slightly more potent in stimulating aldosterone and had a higher metabolic clearance rate than AIL [des-Asp1AII stimulated aldosterone in four of the five sodium-depleted dogs but no steepening of the [des- Asp1AII/aldosterone dose-response curves was apparent. These results do not support the hypothesis that circulating [des-Asp1 aldosterone in the dog.