Secondary structure of the promastigote surface protease of Leishmania
- 5 December 1988
- journal article
- Published by Wiley in FEBS Letters
- Vol. 241 (1-2) , 79-82
- https://doi.org/10.1016/0014-5793(88)81035-4
Abstract
By Raman spectroscopic analysis we have determined the secondary structure of the promastigote surface protease, named PSP or gp63, of Leishmania major. It consist of nearly 50% antiparallel β‐strand, and less than 20% α‐helix. These results are contrasted with the predominantly α‐helical VSGs of the African trypanosomes and the α‐helical metalloprotease thermolysin. The PSP of Leishmania thus represents a novel kind of membrane‐anchored protease.Keywords
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