Tissue inhibitor of metalloproteinases (timp) regulates extracellular type i collagen degradation by chondrocytes and endothelial cells
Open Access
- 1 March 1987
- journal article
- research article
- Published by The Company of Biologists in Journal of Cell Science
- Vol. 87 (2) , 357-362
- https://doi.org/10.1242/jcs.87.2.357
Abstract
A specific antiserum to purified rabbit tissue inhibitor of metalloproteinases (TIMP) was raised in sheep, characterized and used to investigate the role of TIMP in a model system. Chondrocytes and endothelial cells cultured on 14C-labelled type I collagen films and stimulated to produce collagenase were unable to degrade the films unless the anti-TIMP antibody was added. The degradation induced was inhibited by a specific anti-rabbit collagenase antibody. It was concluded that TIMP is a major regulatory factor in cell-mediated collagen degradation.This publication has 21 references indexed in Scilit:
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