Use of the Hammett equation in substituted thiophenes
- 1 January 1985
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 2
- No. 4,p. 485-490
- https://doi.org/10.1039/p29850000485
Abstract
The application of multivariate statistics to linear free-energy relationships in the thiophene series increases the understanding of the Hammett equation. Principal components analysis shows that α-substituted thiophenes require the σ constants used for para-substituted benzene derivatives, owing to a strict proportionality of the substituent effects in the heterocyclic and homocyclic systems. Partial least-squares analysis indicates that two independent effects are linearly transferred from benzenes to thiophenes.Keywords
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