Actions of phencyclidine on the perfused rabbit ear

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Abstract
Phencyclidine potentiated the responses of the rabbit perfused ear and its isolated central artery to noradrenaline, adrenaline and periarterial nerve stimulation. The potentiation of nerve stimulation was more pronounced than the potentiation of exogenous noradrenaline or adrenaline. Where the access of noradrenaline was restricted to one surface of the artery only, phencyclidine caused a much greater potentiation of extraluminal than of intraluminal noradrenaline. A biphasic response to tyramine was observed, the secondary prolonged vasoconstrictor phase being blocked by phencyclidine. It is postulated that phencyclidine inhibits the uptake of both noradrenaline and tyramine by the adrenergic axons in the blood vessel wall in a manner similar to that suggested for cocaine.