An Association of Short Stature, Retarded Sexual Development and High Urinary Gonadotropin Titers in Women1

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Abstract
By alc. precipitation and assay by the mouse uterine wt. method gonadotrophins excreted in normal and castrate or menopausal urine may be measured by their capacity to increase estrin production by the immature mouse ovary. Normal women excreted from less than 10 to as high as 50 M.U. per day, menopausal [female][female] from 100 to 550 M.U. per day. Four short [female][female], 4 ft., 6 in. to 4 ft., 101/2 in. tall, with retarded sexual development, excreted 200 to 500 M.U. per day, values equal to those of the castrate and usually taken to suggest primary ovarian insufficiency. Moderate doses of the material in the urine of 1 subject stimulated the diffuse growth of ovarian follicles and of seminiferous tubules of hypophysectomized rats. These girls were not obese, were fairly well proportioned, showed little breast development and little sexual hair. So far as known, the accessory genitalia were well formed though hypoplastic, and menses occurred infrequently if at all. Retardation in completion of epiphyseal fusion at the wrists was often present in comparison with Todd''s standard but was not regularly distinct there or elsewhere by more liberal standards. B. M. R. was usually normal. Urinary androgens and estrogens were low in the 2 cases studied. No evidence of gross pituitary lesion was adduced on clinical study.

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