Comparison of spirometry criteria for the diagnosis of COPD: results from the BOLD study
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Open Access
- 21 May 2009
- journal article
- research article
- Published by European Respiratory Society (ERS) in European Respiratory Journal
- Vol. 34 (3) , 588-597
- https://doi.org/10.1183/09031936.00164608
Abstract
Published guidelines recommend spirometry to accurately diagnose chronic obstructive pulmonary disease (COPD). However, even spirometry-based COPD prevalence estimates can vary widely. We compared properties of several spirometry-based COPD definitions using data from the international Burden of Obstructive Lung Disease (BOLD)study.14 sites recruited population-based samples of adults aged ≥40 yrs. Procedures included standardised questionnaires and post-bronchodilator spirometry. 10,001 individuals provided usable data.Use of the lower limit of normal (LLN) forced expiratory volume in 1 s (FEV1) to forced vital capacity (FVC) ratio reduced the age-related increases in COPD prevalence that are seen among healthy never-smokers when using the fixed ratio criterion (FEV1/FVC 1either 1/FEV6ratio in place of the FEV1/FVC yielded similar prevalence estimates.Use of the FEV1/FVC1/FVC 1/FEV6as a practical substitute for the FEV1/FVC.Keywords
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