Structural Organization of Unique Retrovirus-like Particles Budding from Human Teratocarcinoma Cell Lines
Open Access
- 1 December 1983
- journal article
- research article
- Published by Microbiology Society in Journal of General Virology
- Vol. 64 (12) , 2549-2559
- https://doi.org/10.1099/0022-1317-64-12-2549
Abstract
Human teratocarcinoma cells cultured in vitro can be induced to produce retroviruslike particles. The induction procedures are the same as those previously shown to induce the synthesis of animal retroviruses. Electron microscopical evidence is presented that the human teratocarcinoma-derived (HTD) particles are most closely related to the type C retrovirus strains. HTD particles can be banded at 1.16 g/ml in linear sucrose gradients, the characteristic density for retroviruses, and subsequently be used for negative staining and fine structure analysis.This publication has 13 references indexed in Scilit:
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