One Pot Synthesis of Cyclobutanols by Ring Expansion of Oxaspiropentanes Induced by Grignard Reagents

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Abstract
Aromatic, aliphatic and vinylic Grignard reagents efficiently catalyze the ring expansion of oxaspiropentanes 2 a,b to give, in one pot, good yields of cyclobutanols 3 a, 3 b - 7 b. Benzyl magnesium chloride gives a mixture of cyclobutanols and the cyclopropanol 8, probably coming from a direct nucleophilic attack on the epoxide part of the oxaspiropentane.

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