INTESTINE-LIKE REMODELING OF ADULT-MOUSE GLANDULAR STOMACH BY IMPLANTING OF FETAL INTESTINAL MESENCHYME

  • 1 January 1984
    • journal article
    • research article
    • Vol. 44  (12) , 5845-5849
Abstract
A morphogenetic response of adult glandular stomach grown in contact which implanted fetal intestinal mesenchyme was demonstrated. Mesenchymal tissues from intestines of 14-16-day-old BALB/c mouse fetuses were introduced beneath the epithelial layer of glandular stomach in 2-mo.-old mice and allowed to develop. Three to 4 wk later, remodeling of the epithelial architecture had occurred; the characteristic glandular pit structure of normal stomach was replaced by immature villi and crypts and composed of mucus-secreting columnar cells more characteristic of intestinal tissues. Chief and parietal cells had disappeared, but neither goblet nor Paneth cells were observed. Such intestine-like morphogenesis was not induced by similarly implanted mesenchymal controls from fetal glandular stomach, forestomach and salivary gland. A possible role of the mesenchymal stroma in the pathogenesis of intestinal metaplasia in stomach is discussed.