RELAPSING FEBRILE NODULAR NONSUPPURATIVE PANNICULITIS (WEBER-CHRISTIAN DISEASE)

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Abstract
Two cases of relapsing febrile nodular nonsuppurative panniculitis were observed at the Massachusetts General Hospital in 1937, and because the number of known cases is so small, it was thought advisable to report them. The characteristic feature of this disease is the recurrence of crops of subcutaneous nodules which either remain separate or become, by confluence, indurated areas of subcutaneous fat. They are usually tender and painful. Malaise and slight fever accompany the appearance of nodules in most cases. The pathologic changes are necrosis of the subcutaneous fat and later inflammation and fibrosis. Usually complete removal of the fat follows, resulting in a sharply circumscribed area of depressed skin. Some nodules, especially the smaller ones, may disappear without leaving any trace. As a rule, no pathologic changes are observed in other parts of the body. In a few cases an enlarged spleen and leukopenia have been reported. The diagnosis of

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