THE GRADATION OF EFFECTIVENESS AND ABSORPTION OF DESOXYCORTICOSTERONE ACETATE PELLETS BY DILUTION WITH CHOLESTEROL1,2

Publisher Website
Google Scholar
Abstract
Since their introduction pellets of steroid hormones have enjoyed wide popularity, both in experimental and clinical medicine (Segaloff 1950). The usefulness of this method was greatly extended by Shimkin’s suggestion that pellets diluted with cholesterol are absorbed at a slower rate. There has been one experiment of which I am aware in which absorption of the cholesterol diluent was assessed by direct measurement of the cholesterol (Fuenzalida, 1944), and another in which the active steroid was measured by biologic assay (Shimkin, 1941). However, I know of no study in which an attempt was made to correlate the possible gradations of both effectiveness and absorption of the active steroid when progressive dilutions with cholesterol were employed. This report represents our first attempt to correlate effectiveness and absorption in pellets diluted with progressively larger amounts of cholesterol. MATERIALS AND METHODS Two types of desoxycorticosterone acetate (hereafter called DCA) pellets were employed.

This publication has 1 reference indexed in Scilit: