Acute demyelinating disease in a chimpanzee three years after inoculation of brain cells from a patient with MS
- 1 January 1979
- journal article
- case report
- Published by Wiley in Annals of Neurology
- Vol. 5 (1) , 89-94
- https://doi.org/10.1002/ana.410050113
Abstract
Brain cells from a patient with classic multiple sclerosis were inoculated intracerebrally into the frontal lobe of a newborn chimpanzee. The animal developed acute quadriplegia three years, two months later and was killed four days after the onset of symptoms. Central nervous system lesions were primarily localized in the spinal cord at root entry zones; these were characterized by demyelination and regeneration of myelin by Schwann cells.Keywords
This publication has 8 references indexed in Scilit:
- Central Nervous System Susceptibility to Herpes Simplex InfectionJournal of Neuropathology and Experimental Neurology, 1978
- ISOLATION OF HERPES SIMPLEX VIRUS FROM HUMAN TRIGEMINAL GANGLIA, INCLUDING GANGLIA FROM ONE PATIENT WITH MULTIPLE SCLEROSISThe Lancet, 1977
- Human brain in tissue cultureJournal of the Neurological Sciences, 1976
- Human brain in tissue culture. IV. Morphological characteristicsJournal of Comparative Neurology, 1975
- Human brain in tissue culture. II. Studies of long‐term culturesJournal of Comparative Neurology, 1975
- Human brain in tissue culture. I. Acquisition, initial processing, and establishment of brain cell culturesJournal of Comparative Neurology, 1975
- Theiler's virus infection in mice: an unusual biphasic disease process leading to demyelinationInfection and Immunity, 1975
- Pathogenesis of Demyelination Induced by a Mouse HepatitisArchives of Neurology, 1973