A specific histochemical marker (lectinRicinus communis agglutinin-1) for normal human microglia, and application to routine histopathology

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Abstract
Microglia were demonstrated in paraffinembedded human nervous tissues with an avidinbiotin peroxidase method andRicinus communis agglutinin-1 (RCA-1). Specific staining was observed in cell bodies and processes of microglia. Although endothelial cells and blood cells reacted with RCA-1, they were easily distinguished morphologically from microglia. Astrocytes, oligodendrocytes, and neurons did not react with RCA-1. These results suggest that RCA-1 can be used as a new histochemical marker for microglia in normal human brain.