Duration of the Local Anesthetic Action of Dibucaine by Liposomes and Its Mechanism

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Abstract
Duration of anesthetic action of dibucaine in the presence of liposomes was studied, using intradermal wheal methods in guinea pigs. The intermolecular interaction of dibucaine and liposomes was studied in vitro to investigate the mechanism of the duration effect. When dibucaine was absorbed by the liposomes, the decay of the anesthetic action of the drug was inhibited and the duration time of anesthesia was prolonged. In the case of liposomes composed of phosphatidylcholine and cholesterol, the degree of anesthesia was directly correlated with the percentage of apparent absorbed dibucaine. Ionic interaction may have played an important role in the binding of dibucaine and liposome having a negative charge.