Fragment-based lead discovery
Top Cited Papers
- 1 August 2004
- journal article
- review article
- Published by Springer Nature in Nature Reviews Drug Discovery
- Vol. 3 (8) , 660-672
- https://doi.org/10.1038/nrd1467
Abstract
No abstract availableKeywords
This publication has 51 references indexed in Scilit:
- Ligand efficiency: a useful metric for lead selectionDrug Discovery Today, 2004
- Identification of Novel Binding Interactions in the Development of Potent, Selective 2-Naphthamidine Inhibitors of Urokinase. Synthesis, Structural Analysis, and SAR of N-Phenyl Amide 6-SubstitutionJournal of Medicinal Chemistry, 2003
- Requirements for Specific Binding of Low Affinity Inhibitor Fragments to the SH2 Domain ofpp60Src Are Identical to Those for High Affinity Binding of Full Length InhibitorsJournal of Medicinal Chemistry, 2003
- A ‘Rule of Three’ for fragment-based lead discovery?Drug Discovery Today, 2003
- Molecular Properties That Influence the Oral Bioavailability of Drug CandidatesJournal of Medicinal Chemistry, 2002
- Molecular Complexity and Its Impact on the Probability of Finding Leads for Drug DiscoveryJournal of Chemical Information and Computer Sciences, 2001
- Design, Synthesis, and Characterization of a High-Affinity Trivalent System Derived from Vancomycin and l-Lys-d-Ala-d-AlaJournal of the American Chemical Society, 2000
- The Design of Leadlike Combinatorial LibrariesAngewandte Chemie International Edition in English, 1999
- Tight Binding of a Dimeric Derivative of Vancomycin with Dimeric l-Lys-d-Ala-d-AlaJournal of the American Chemical Society, 1997
- Discovering High-Affinity Ligands for Proteins: SAR by NMRScience, 1996