Pulmonary edemafolloing ingestion of hydrochlorothiazide

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Abstract
Pulmonary edema developed in 2 women (44 and 65 years of age) within 45 min. after they had ingested single 50-mg tablets of hydrochloro-thiazide. There was no history of heart disease, and the drug was taken for weight reduction in 1 patient and for mild hypertension in the other. On admission to the hospital. X-ray films of the chest showed congestive changes in the lungs. The arm-to-tongue circulation time was normal Clinical and laboratory data did not support a /diagnosis of myocardial infarction or pulmonary embolus. It is postulated that these were idiosyncreatic reactions to the drug.

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