Presynaptic Membrane Protein Phosphorylation Modulates the Release of GABA from Preloaded Synaptosomes
- 1 August 1980
- journal article
- Published by Wiley in Journal of Neurochemistry
- Vol. 35 (2) , 506-508
- https://doi.org/10.1111/j.1471-4159.1980.tb06295.x
Abstract
Incubation of rat cortical synaptosomes in the presence of 1 mM ATP markedly reduced Ca2+-dependent K+-induced release of preloaded 3H-GABA. This effect is probably dependent on phosphorylation of presynaptic membrane proteins. By contrast, the uptake of 3H-GABA by the nerve endings was not significantly affected by phosphorylation. These data suggest that membrane protein phosphorylation and dephosphorylation may form a mechanism for the presynaptic control of transmitter release.Keywords
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