VIRULENT-AVIRULENT CONVERSIONS OF Rickettsia Rickettsii IN VITRO
- 15 November 1955
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 41 (11) , 870-873
- https://doi.org/10.1073/pnas.41.11.870
Abstract
In this paper is reported (a) the in vitro conversion of virulent R. rickettsii to an avirulent state by para-aminobenzoic acid; (b) the in vitro reactivation or conversion of the PABA-avirulent and arthropod-avirulent rickettsiae to the virulent form by the addition of Coenzyme I or Coenzyme A; and (c) the observation that the state of virulence for guinea pigs parallels the adsorptivity of R. rickettsii to minced guinea pig tunica.Keywords
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