Interstitial Cystitis and Panic Disorder

Open Access
Publisher Website
Google Scholar
Abstract
We report results from a study designed to follow up genetic linkagefindings of a previously unidentified syndrome in some multiplex familieswith panic disorder (PD).1 This syndrome includedPD, various urinary problems (possibly interstitial cystitis [IC]), thyroiddisorders, mitral valve prolapse (MVP), and/or chronic headaches/migrainein some family members. The genetic linkage study had selected the familiesbased on initial evidence of at least 3 family members affected with PD.2,3 While the information on PD was obtainedfrom careful interviews, information on the bladder problems and other medicalconditions was obtained only through medical records and history checklists.By using these less-than-definitive methods for the medical conditions, logarithmof odds scores of 4.2 on chromosome 13 (marker D13S779)were obtained in the first 19 multiplex families with PD and these other medicalconditions.1 These findings were further supportedin a genome scan performed on an extended sample that included the initial19 families and an additional 41 families, for a total of 60 multiplex familieswith 587 individuals.4

This publication has 22 references indexed in Scilit: