Mitochondrial DNA 5178A polymorphism and longevity
- 1 October 2002
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 111 (4-5) , 462-463
- https://doi.org/10.1007/s00439-002-0826-z
Abstract
Previous studies have shown that mitochondrial DNA (mtDNA) 5178 adenine/cytosine (5178A) polymorphism, which is one of the haplogroup-specific mutations for mtDNA haplogroup D, was apparently associated with aging and longevity in humans. We genotyped the 5178A in 293 samples representing three age groups (Old, n=95; Young, n=103; and Infant, n=95) from Yunnan Province, China. The distribution frequency of the 5178A in the Old samples (16.84%) is slightly higher than in those of the Young (13.59%) and Infant (15.79%), but the frequency difference between the age groups is far from being statistically significant (P>0.05). Our results fail to support the suggestion of association between mtDNA 5178A (or haplogroup D) and longevity.Keywords
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