A Bacterial Binding Site Which Binds Human Chorionic Gonadotropin but not Human Luteinizing Hormone
- 1 January 1992
- journal article
- research article
- Published by Taylor & Francis in Endocrine Research
- Vol. 18 (1) , 51-58
- https://doi.org/10.3109/07435809209035928
Abstract
Exposed sites on Pseudomonas maltophilia (ATC #1637), which bind both human chorionic gonadotropin (hCG) and a native hCG-like ligand with equal high affinity, are described. This high-affinity binding site (Kd = 1.3 x 10(-10) binds hCG, but does not bind human luteinizing hormone (hLH), nor related human glycoprotein hormones, thyrotropin, and follicle stimulating hormone. A lower affinity, 2.3 x 10(-9), is also described which binds hLH and hCG equally well. This is the first description of a high-affinity binding site in nature, which distinguishes hCG from hLH.Keywords
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