Proliferation of Erythroblasts in Refractory Anaemia

1 January 1974

journal article
Published by S. Karger AG in Acta Haematologica

Vol. 52 (5) , 257-264
https://doi.org/10.1159/000208249

Abstract

Combined cytophotometric-autoradiographic investigations of erythropoiesis in refractory anaemia with hypercellular bone marrow showed a decreased percentage of DNA synthetizing basophilic and polychromatic erythroblasts with an increase of the percentage in G₁ In some cases an additional increase of the percentage in G₂, respectively a decreased S:G₂ ratio was found. The disturbance of cell proliferation is one factor leading to an ineffective cell production but was not found in 3 of the 10 patients with refractory anaemia.

Keywords

AUTORADIOGRAPHY
CYTOPHOTOMETRY
DNA SYNTHESIS
ERYTHROPOIESIS
PRELEUKAEMIA
REFRACTORY ANAEMIA

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