Effect of Estradiol and Ethynylestradiol on Microtubule Distribution in Chinese Hamster V79 Cells.

1 January 1992

journal article
Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN

Vol. 40 (1) , 182-184
https://doi.org/10.1248/cpb.40.182

Abstract

The effects of estradiol (E2) and ethynylestradiol (EE2) on the chromosome number and cellular microtubule architecture of Chinese hamster V79 cells were studied using fluorescent anti-tubulin antibody. Treatment with 20 microM E2 for 48 h induced only a small amount of tetraploid cells, but the normal microtubule network was disrupted completely by only 3 h of treatment. This data reveals that E2 has higher microtubule-disruptive activity than diethylstilbestrol in V79 cells.

Keywords

ARCHITECTURE
TETRAPLOID
FLUORESCENT
ETHYNYLESTRADIOL
V79
TREATMENT
ANTIBODY
DISRUPTED
HAMSTER

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