Increased Graft-Versus-Host Susceptibility of Thymectomized Recipients.

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Abstract
Summary Thymectomy performed immediately after birth increases the susceptibility of (C3H X A)F1 recipients to development of splenomegaly following the injection of spleen cells from A and C3H mice, and of C3H recipients to produce splenomegaly following the injection of spleen cells from A mice. In view of current knowledge, that much of the splenomegaly in grait-versus-host reaction is due to proliferation of host cells, our experiments indicate that this proliferation does not involve thymus dependent im-munocompetent cells of the host. These findings stress once again the susceptibility of the neonatally thymectomized recipient mouse to the development of homologous disease after injection of homologous cells which are readily rejected by the intact recipients. The findings have important implication in efforts to design and execute replacement therapy for humans genetically or developmentally lacking in thymic system of lymphocytes.

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