Inhibition of DNA Polymerase from Herpes Simplex Virus-Infected Wi-38 Cells by Phosphonoacetic Acid
- 1 May 1975
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 15 (5) , 1281-3
- https://doi.org/10.1128/jvi.15.5.1281-1283.1975
Abstract
Infection of Wi-38 cells with herpes simplex virus induced an elevated DNA polymerase activity which had many biochemical properties different from normal cell DNA polymerase. Phosphonoacetic acid specifically inhibited the virus-induced DNA polymerase as compared to the normal WI-38 cell DNA polymerase. The compound did not appear to inhibit enzyme activity by interacting with the DNA primer.Keywords
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