Variations in cardiac output associated with hemoglobin levels in anesthetized sheep

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Abstract
Hemoglobin levels in sheep was found to be related inversely to the logarithm of cardiac index and directly to the calculated systemic and pulmonary arterial resistances over a wide spectrum of hemoglobin concentrations including the normal range. It appeared to be based on changes in blood viscosity produced by a varying red cell concentration. The continuous adjustment of hemoglobin levels and cardiac output may account for the variability of cardiac output values in normal laboratory animals and may represent a mechanism maintaining oxygen delivery to the tissues in the presence of changing oxygen carrying capacity. blood viscosity; vascular resistance; oxygen carrying capacity Submitted on May 15, 1964

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