Pharmacokinetics of 2-Pivaloylindan-1,3-Dione in Dogs

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Abstract
The pharmacokinetics of 2-pivaloylindan-1,3-dione (Pival) after administration of a single dose was investigated in dogs. The plasma concentration graph can be described by a 1 compartment open model. The drug is fairly well absorbed (67%), and the excretion is extremely slow with a half-life of nearly 5 days. These kinetics can be explained by the physicochemical properties of the drug, such as strong binding to canine plasma protein, high lipophility and the lack of transformation to polar metabolites. A single oral dose of 5 mg/kg must be regarded as lethal to dogs, and the LD50 is assumed to be approximately 4 mg/kg in this species.