The Development of Cochlear Frequency Resolution in the Human Auditory System

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Abstract
The objectives of this study were: 1) to evaluate the maturity of cochlear frequency resolution in human neonates, and 2) to further elucidate the differential time course for development of frequency resolution at the cochlear and auditory-neural levels of the auditory system. This paper describes a relatively new technique using distortion product otoacoustic emision (DPOAE) suppression to study cochlear tuning. DPOAE suppression tuning curves (STCs) were generated in 15 normal-hearing adults and 26 healthy, term-born neonates at 1500, 3000, and 6000 Hz. The 2f1-f2 DPOAE was measured in all subjects with primary tones of 65 and 50 dB SPL (L1 > L2) and a 1.22 f2/f1 frequency ratio. Initially, an unsuppressed DPOAE was recorded. After this, a suppressor tone was introduced, and its level varied until DPOAE amplitude was reduced by 6 dB. By plotting the suppressor level required to achieve criterion amplitude reduction by suppressor frequency (for many tones), a DPOAE STC was generated. DPOAE STC shape, width, slope, and tip characteristics were analyzed for both adults and neonates. General shape and appearance of DPOAE STCs were comparable for adults and neonates, as was STC tip frequency and level. Statistical analyses of tuning-curve width (Q) and slope (dB/octave) failed to show age effects, further confirming the similarity between adults and neonates. DPOAE STCs were stable, show minimal intra- and intersubject variability, and closely resemble and behave like physiologic measures of tuning from the VIIIth nerve. Results suggest that: 1) cochlear tuning and related active processes are basically mature by term birth in the human auditory system, 2) tuning immaturities reported in infants as old as 6 mo of age probably involve auditory-neural immaturities, and 3) suppression of the 2f1-f2 DPOAE seems, to provide an indirect measure of cochlear frequency resolution in humans.