Oxytocin contracts the human uterus at term by inhibiting the myometrial Ca2+-extrusion pump

1 January 1985

journal article
research article
Published by Portland Press Ltd. in Bioscience Reports

Vol. 5 (1) , 21-28
https://doi.org/10.1007/bf01117437

Abstract

The sarcolemma of smooth-muscle ceils from human pregnant myometrium possesses a high-affinity Ca2+-ATPase, which has the characteristics of an active Ca2+-extrusion pump. This pump enzyme, either membrane-bound or solubilized, was strongly inhibited by oxytocin (half-maximal inhibition at about 4 μU/ml or 10 pM). However, under similar conditions, oxytocin did not inhibit Ca2+extrusion ATPase of the erythrocyte membrane. The inhibitory concentrations of oxytocin correspond to hormone plasma levels which initiate spontaneous labor.

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