The dimensions of the particle of hyaluronic acid complex in synovial fluid

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Abstract
Measurements were made on ox synovial fluid, dialyzed against buffer containing 0.2 [image] NaCl, 0.0077 [image] Na2HPO4 and 0.0023 [image] KH2PO4 (pH 7.3) of (a) the variation of viscosity with concn., velocity gradient and temp.; the variations of the angle of isocline and the birefringence with concn. and velocity gradient at 25[degree]. The results of these measurements are discussed in connection with data on sedimentation and diffusion. It is concluded that all the evidence is consistent with the particles of hyaluronic acid complex being nearly spherical and very highly solvated; that the hyaluronic acid complex is probably a chain polymer; and that the variation of viscosity with velocity gradient can be explained in terms of interaction between particles.

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