Antiproliferative Effects of Melatonin and CGP 52608
- 19 March 1999
- journal article
- research article
- Published by S. Karger AG in Neurosignals
- Vol. 8 (1-2) , 75-78
- https://doi.org/10.1159/000014572
Abstract
The antiproliferative effects of melatonin and CGP 52608, an exogenous ligand for RZR/ROR receptors, are compared in the present paper. Both compounds exerted similar inhibitory effects on the proliferation of neoplastic cells in mouse colonic adenocarcinoma, DU 145 human prostate cancer, MCF-7 human breast carcinoma, and rat diethylstilbestrol-induced prolactinoma. Although it has been suggested that melatonin may influence the proliferation of tumor cells via RZR/ROR receptors, it cannot be excluded that the antiproliferative effects of melatonin and CGP 52608 are unrelated and mediated by different intracellular mechanisms.Keywords
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