Lipide Synthesis by Arterial and Liver Tissue Obtained From Cholesterol-Fed and Cholesterol-Alcohol-Fed Rabbits

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Abstract
Feeding of alcohol with cholesterol had no effect on elevated tissue lipid concentrations or on the induced hypercholesterolemia of cholesterol-fed rabbits. Sclerotic arterial tissue converted acetate-2-C-14 to radioactive fatty acids, non-saponifiable lipids and CO2 to the same extent as normal arterial tissue. Tracer studies indicate that hepatic cholesterol as well as hepatic fatty acid synthesis was greatly depressed following cholesterol feeding. There was no concomitant reduction in oxidation of acetate. The reduction of lipogenesis and cholestero-genesis found in liver slices was not observed for arterial tissue. These results were not altered by concomitant alcohol feeding.