The mechanism of DNA strand breakage by vitamin C and superoxide and the protective roles of catalase and superoxide dismutase
- 1 May 1976
- journal article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 3 (5) , 1139-1150
- https://doi.org/10.1093/nar/3.5.1139
Abstract
Vitamin C breaks DNA only in the presence of oxygen. Superoxide dismutase has no effect on the reaction but catalase suppresses it. Superoxide also gives rise to breaks in DNA suppressible by both superoxide dismutase and catalase. The hydroxyl radical seems to be the agent responsible for strand cleavage itself.Keywords
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