The Proteasome
Open Access
- 1 November 2001
- journal article
- review article
- Published by Oxford University Press (OUP) in American Journal of Clinical Pathology
- Vol. 116 (5) , 637-646
- https://doi.org/10.1309/44hw-5ycj-fllp-3r56
Abstract
The proteasome is an enzyme present in all cells, from yeast to human, and has a central role in the proteolytic degradation of the vast majority ofKeywords
This publication has 53 references indexed in Scilit:
- IκB-independent control of NF-κB activity by modulatory phosphorylationsPublished by Elsevier ,2001
- Proteasome inhibitors: fromin vitro uses to clinical trialsJournal of Peptide Science, 2000
- Control of inducible chemoresistance: Enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-κBNature Medicine, 1999
- Prostate carcinoma cell death resulting from inhibition of proteasome activity is independent of functional Bcl-2 and p53Oncogene, 1998
- Novel dipeptidyl proteasome inhibitors overcome Bcl-2 protective function and selectively accumulate the cyclin-dependent kinase inhibitor p27 and induce apoptosis in transformed, but not normal, human fibroblastsCell Death & Differentiation, 1998
- THE NF-κB AND IκB PROTEINS: New Discoveries and InsightsAnnual Review of Immunology, 1996
- Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by LactacystinScience, 1995
- The ubiquitin-proteasome proteolytic pathwayCell, 1994
- The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κBCell, 1994
- Evidence for the presence of five distinct proteolytic components in the pituitary multicatalytic proteinase complex. Properties of two components cleaving bonds on the carboxyl side of branched chain and small neutral amino acidsBiochemistry, 1993