Effect of Anesthetics and Collection Time on Corticosteroid Secretion By Rat Adrenal.

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Abstract
Summary Secretion of corticosterone into the adrenal venous effluent of the rat was markedly influenced during the first 10 minutes of collection by the nature of the anesthetic employed for cannulation procedure. Ether anesthesia resulted in a significant elevation of corticosterone concentration and corticosterone flow rate during this period as compared with the values observed when Nembutal was used. This difference was eradicated during subsequent collection periods of 10 to 25 minutes and 25 to 85 minutes following cannulation. The relationship of these findings to the possible activation by ether and inhibition by Nembutal of the pituitary-adrenocortical system is discussed.

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