PIGMENT EPITHELIAL-CELLS IN CULTURE - METABOLIC PATHWAYS REQUIRED FOR PHAGOCYTOSIS

  • 1 January 1981
    • journal article
    • research article
    • Vol. 20  (1) , 1-7
Abstract
The phagocytosis of bovine rod outer segments as measured by the uptake of 3H-labeled outer segments was studied in a culture system. Phagocytosis was markedly inhibited by the lack of glucose and by 2 inhibitors of the tricarboxylic acid cycle-cytochrome system, dinitrophenol and malonate. Lactate production was increased in phagocytizing cells, but the hexose monosphosphate shunt was not stimulated. The tricarboxylic acid cycle and its associated cytochrome system apparently play an important role as an energy source for phagocytosis in these cells. Compromise of this energy source rapidly leads to a suppression of the phagocytic process.

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