Development of Resistance and Cross-Resistance in vitro to Erythromycin, Carbomycin, Spiramycin, Oleandomycin and Streptogramin.

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Abstract
Four strains of Micrococcus aureus were rendered resistant to erythromycin, Carbomycin, Oleandomycin, Spiramycin and Streptogramin by repeated subcultures in the presence of increasing concentrations of these antibiotics. Cross-resistance to about the same degree developed to all of these agents except to Streptogramin; the latter produced homologous resistance at a slower rate than the others, but this was associated with a corresponding increase in cross-resistance to the other 4 antibiotics.