USE OF SYNTHESIS INHIBITORS IN DEFINING A ROLE FOR BIOGENIC-AMINES DURING IMIPRAMINE TREATMENT IN DEPRESSED-PATIENTS

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  • 1 January 1975
    • journal article
    • research article
    • Vol. 1  (2) , 239-249
Abstract
Endogenously depressed patients who showed an antidepressant response to the tricyclic drug imipramine continued to show sustained well being after .alpha.-MPT [.alpha.-methyl-p-tyrosine] was added whereas depression returned when small doses of PCPA [p-chlorophenylalanine] were added for brief periods. In 1 patient the antidepressant response to imipramine occurred after pre- and continued treatment with .alpha.-MPT. Urinary excretion levels of MHPG [3-methoxy-4-hydroxyphenylglycol] in 1 of the patients studied longitudinally did not correspond to the direction of clinical affective state but did reflect anticipated changes during .alpha.-MPT treatment. Serotonergic mechanisms are probably involved in the antidepressant effects of imipramine in man.

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