Assignment of the mouse homologue of a human MEN1 candidate gene, phospholipase C-β3 (Plcb3), to chromosome region 19B by FISH
- 1 January 1995
- journal article
- animal cytogenetics-and-comparative-mapping
- Published by S. Karger AG in Cytogenetic and Genome Research
- Vol. 71 (3) , 257-259
- https://doi.org/10.1159/000134122
Abstract
A recent study using comparative mapping analysis suggests that the proximal segment of mouse chromosome 19 contains the mouse homologs of the human multiple endocrine neoplasia type 1 (MENl) flanking markers proximal to the locus. We have recently shown that phospholipase C-β3 (PLCB3) is a candidate gene for the MENl syndrome. In the present investigation we used fluorescence in situ hybridization with a genomic DNA clone for mouse Plcb3, and mapped the locus to chromosome region 19B. This is in agreement with the comparative mapping of the MENl flanking markers in mouse.Keywords
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